Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Across TCGA cell cohorts, RNA activity of the Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGTLC2, SRSF5, and MANBAL, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GGTLC2 grouped by Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GGTLC2 →	-0.260	-1.807	.009	.005	3	1
BREAST	SRSF5 →	+0.345	+1.694	.001	<.001	3	1
BREAST	MANBAL →	+0.245	+1.694	.008	<.001	3	1
BREAST	TUSC3 →	-0.270	-1.818	.005	.005	3	1
BREAST	RNASEH2A →	+0.255	+1.731	.006	.001	3	1
BREAST	RUNDC3B →	+0.243	+1.694	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GGTLC2 by Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand activity — BREAST

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