Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Across TCGA cell cohorts, RNA activity of the Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM184B, ITIH4, and SLC25A17, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand activity versus TMEM184B in BREAST (Pearson r = -0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMEM184B →	-0.995	-1.807	.007	.005	2	2
BLOOD_Leukemia	ITIH4 →	+2.415	+0.351	.007	.008	2	1
BREAST	SLC25A17 →	-0.884	-1.807	.005	.005	2	1
BREAST	L3MBTL2 →	-0.819	-1.807	.001	.005	2	1
BREAST	CEP128 →	+1.095	+1.807	.007	.005	2	1
BREAST	EFS →	-4.725	-1.807	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001241 vs TMEM184B — BREAST

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