Regulation of extrinsic apoptotic signaling pathway in absence of ligand

Across TCGA patient cohorts, RNA activity of the Regulation of extrinsic apoptotic signaling pathway in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FUT3, LINC01120, and AK4P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extrinsic apoptotic signaling pathway in absence of ligand activity versus FUT3 in LSCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FUT3 →	-0.853	-0.172	.002	.006	3	4
PDAC	LINC01120 →	+0.031	+0.136	.002	.002	3	3
LUAD	AK4P1 →	+0.451	+0.115	<.001	.003	3	3
PDAC	RLF →	+0.313	+0.166	.003	.003	3	3
LSCC	FUT6 →	-0.665	-0.180	.001	.004	3	3
PDAC	FN1 →	+0.586	+0.119	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001239 vs FUT3 — LSCC

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