Regulation of extrinsic apoptotic signaling pathway in absence of ligand

Across TCGA cell cohorts, RNA activity of the Regulation of extrinsic apoptotic signaling pathway in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD54, TRIM2, and BCL2L1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extrinsic apoptotic signaling pathway in absence of ligand activity versus ANKRD54 in BREAST (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANKRD54 →	-0.617	-0.820	.003	.001	2	7
URINARY_TRACT	TRIM2 →	-1.328	-1.387	.003	.004	3	5
SOFT_TISSUE	BCL2L1 →	+1.490	+0.722	.003	.002	2	6
STOMACH	UQCRHL →	-1.079	-1.161	.006	.002	3	5
URINARY_TRACT	TBX19 →	-0.792	-1.630	.003	<.001	3	4
OESOPHAGUS	CSF1R →	-0.308	-0.864	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001239 vs ANKRD54 — BREAST

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