Positive regulation of extrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of extrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRE2, GFPT2, and BIN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extrinsic apoptotic signaling pathway activity versus ADGRE2 in GBM (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADGRE2 →	+0.688	+0.210	<.001	.001	3	7
HNSC	GFPT2 →	+1.026	+0.167	<.001	<.001	3	7
GBM	BIN2 →	+0.828	+0.313	<.001	<.001	3	7
GBM	CD86 →	+0.717	+0.173	<.001	<.001	3	7
HNSC	CD80 →	+0.815	+0.172	.007	.002	3	7
GBM	NCKAP1L →	+0.610	+0.171	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001238 vs ADGRE2 — GBM

Explore this scatter interactively →