Positive regulation of extrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of extrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV2, PSMB8, and SP100, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extrinsic apoptotic signaling pathway activity versus CAV2 in STOMACH (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CAV2 →	+5.292	+1.210	<.001	.002	3	8
KIDNEY	PSMB8 →	+0.905	+0.265	<.001	<.001	3	7
SOFT_TISSUE	SP100 →	+4.235	+1.773	.001	<.001	3	7
STOMACH	CAV1 →	+5.061	+1.193	.003	.003	3	7
STOMACH	DDX60L →	+2.502	+0.996	.001	.007	2	8
BREAST	PYM1 →	-0.840	-1.161	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001238 vs CAV2 — STOMACH

Explore this scatter interactively →