Negative regulation of extrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of extrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCLK2, SERPINH1, and ARHGEF17, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extrinsic apoptotic signaling pathway activity versus DCLK2 in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DCLK2 →	+0.624	+0.129	<.001	<.001	3	7
LSCC	SERPINH1 →	+0.967	+0.193	.001	.001	3	6
BRCA	ARHGEF17 →	+0.624	+0.139	<.001	.002	3	6
UCEC	LMNA →	+1.654	+0.162	.002	<.001	3	6
BRCA	COL18A1 →	+0.872	+0.120	.001	.004	3	6
HNSC	FADS3 →	+0.994	+0.113	.002	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001237 vs DCLK2 — BRCA

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