Negative regulation of extrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of extrinsic apoptotic signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDHGA3, MLC1, and GTPBP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCDHGA3 grouped by Negative regulation of extrinsic apoptotic signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCDHGA3 →	-0.383	-1.008	.004	.009	2	6
SKIN	MLC1 →	-0.303	-0.173	.006	.002	3	5
BLOOD_Leukemia	GTPBP3 →	-0.248	-0.610	.001	.005	3	4
BLOOD_Leukemia	NPTN →	-0.444	-0.887	<.001	.007	3	4
BLOOD_Leukemia	MORC3 →	-0.604	-1.277	<.001	.005	2	5
PANCREAS	GTPBP1 →	-0.359	-0.260	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCDHGA3 by Negative regulation of extrinsic apoptotic signaling pathway activity — BLOOD_Leukemia

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