Negative regulation of extrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of extrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD59, PHLDB1, and DCBLD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extrinsic apoptotic signaling pathway activity versus CD59 in LIVER (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CD59 →	+2.379	+0.248	.001	.004	3	7
URINARY_TRACT	PHLDB1 →	+1.657	+0.232	.001	.002	3	7
LIVER	DCBLD2 →	+3.050	+0.210	.001	.006	3	7
BONE	NT5E →	+4.094	+0.412	.001	.005	3	6
BONE	TGFBR2 →	+3.041	+0.412	.003	.005	3	6
BONE	CAVIN3 →	+4.495	+0.435	.005	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001237 vs CD59 — LIVER

Explore this scatter interactively →