Regulation of extrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of extrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIAS3, RTBDN, and ISLR, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIAS3 grouped by Regulation of extrinsic apoptotic signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PIAS3 →	+1.301	+0.247	.002	<.001	3	3
STOMACH	RTBDN →	-0.636	-0.262	<.001	<.001	3	3
PANCREAS	ISLR →	+0.224	+0.210	.005	.001	3	3
OESOPHAGUS	CHRNB1 →	+2.156	+0.239	.001	.003	3	3
UPPER_AERODIGESTIVE_TRACT	C3 →	+3.073	+0.178	.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	ZSWIM4 →	+1.293	+0.200	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIAS3 by Regulation of extrinsic apoptotic signaling pathway activity — STOMACH

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