Regulation of extrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of extrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, DCBLD2, and ITGA3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extrinsic apoptotic signaling pathway activity versus LGALS1 in BONE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LGALS1 →	+5.057	+0.442	.003	.002	3	9
STOMACH	DCBLD2 →	+3.695	+0.344	<.001	.002	3	9
LIVER	ITGA3 →	+4.977	+0.309	<.001	.002	3	9
STOMACH	SP100 →	+2.535	+0.361	.001	<.001	3	9
LIVER	AHNAK2 →	+5.537	+0.466	<.001	.001	3	9
SOFT_TISSUE	SH3KBP1 →	+2.594	+0.348	.002	.002	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001236 vs LGALS1 — BONE

Explore this scatter interactively →