Positive regulation of apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKDCC, CPPED1, and GAS6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKDCC grouped by Positive regulation of apoptotic signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PKDCC →	-1.380	-0.114	<.001	.007	3	4
STOMACH	CPPED1 →	-1.617	-0.187	.007	<.001	3	3
STOMACH	GAS6 →	-2.246	-0.150	.003	<.001	3	3
LUNG_SCLC	CCDC88B →	-1.786	-0.173	.001	.003	3	3
URINARY_TRACT	MAP3K8 →	+1.815	+0.231	.004	.002	3	3
SKIN	EIF4A2 →	+0.438	+0.135	.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKDCC by Positive regulation of apoptotic signaling pathway activity — SKIN

Explore this box plot interactively →