Positive regulation of apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOLPP1, DDX11, and FAM83D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of apoptotic signaling pathway activity versus DOLPP1 in OVARY (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DOLPP1 →	-0.582	-0.179	.002	.002	3	5
SOFT_TISSUE	DDX11 →	-1.151	-0.212	.002	.008	3	5
SOFT_TISSUE	FAM83D →	-1.043	-0.235	.004	.002	3	5
OVARY	TMEM97 →	-1.173	-0.290	<.001	<.001	3	4
OVARY	ELK3 →	+1.222	+0.201	.004	.003	3	4
BLOOD_Leukemia	PIK3R3 →	-1.113	-0.186	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001235 vs DOLPP1 — OVARY

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