Negative regulation of apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCRIB_T607, SYTL2, and TJP1_T354, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of apoptotic signaling pathway activity versus SCRIB_T607 in COAD (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SCRIB_T607 →	-1.185	-0.193	<.001	<.001	3	1
COAD	SYTL2 →	-0.757	-0.215	.002	.004	3	1
COAD	TJP1_T354 →	-0.400	-0.199	.001	<.001	3	1
COAD	UGT1A10 →	-1.120	-0.176	.001	<.001	3	1
COAD	BOD1L1_S3019 →	+0.653	+0.177	.001	<.001	3	1
COAD	CHGB_S225 →	-0.787	-0.192	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001234 vs SCRIB_T607 — COAD

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