Negative regulation of apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF9, CFLAR, and FNDC3B, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of apoptotic signaling pathway activity versus IRF9 in STOMACH (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	IRF9 →	+1.796	+0.060	.005	.005	3	17
BLOOD_Lymphoma	CFLAR →	+1.642	+0.044	<.001	<.001	3	14
BONE	FNDC3B →	+1.652	+0.067	<.001	<.001	3	14
STOMACH	LAMP2 →	+1.285	+0.069	<.001	.001	3	14
STOMACH	SDC4 →	+3.190	+0.082	<.001	.001	3	14
SOFT_TISSUE	SYNPO →	+1.968	+0.059	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001234 vs IRF9 — STOMACH

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