Negative regulation of apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A4, ACTN1, and LGALS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of apoptotic signaling pathway activity versus SLC22A4 in BLOOD_Leukemia (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC22A4 →	+1.625	+0.175	<.001	<.001	3	7
OESOPHAGUS	ACTN1 →	+1.171	+0.147	.005	.008	3	7
BREAST	LGALS1 →	+3.270	+0.152	<.001	<.001	3	7
BREAST	INHBA →	+3.605	+0.235	<.001	<.001	3	6
BREAST	HRH1 →	+1.287	+0.130	.001	.001	3	6
OESOPHAGUS	MT2A →	+4.352	+0.231	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001234 vs SLC22A4 — BLOOD_Leukemia

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