Regulation of neuron migration

Across TCGA patient cohorts, RNA activity of the Regulation of neuron migration pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL14A1, GEM_S23, and ZHX2_T37, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron migration activity versus COL14A1 in COAD (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COL14A1 →	-0.729	-0.034	<.001	<.001	3	5
COAD	GEM_S23 →	-0.844	-0.033	.001	.002	3	5
HNSC	ZHX2_T37 →	-0.432	-0.027	<.001	.008	3	4
HNSC	NSF →	-0.272	-0.046	<.001	.001	3	4
GBM	NKAP_S157 →	-0.745	-0.064	.003	.003	3	4
LSCC	MAPRE3_S162 →	-0.609	-0.030	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001222 vs COL14A1 — COAD

Explore this scatter interactively →