Positive regulation of vasculogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of vasculogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2-AS1, IGIP, and SFRP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vasculogenesis activity versus ACTA2-AS1 in HNSC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ACTA2-AS1 →	+0.504	+0.611	.002	.004	3	5
LSCC	IGIP →	+0.264	+0.397	.001	.003	3	5
HNSC	SFRP4 →	+1.573	+0.624	.001	.002	3	4
HNSC	DDR2 →	+0.578	+0.511	<.001	.005	3	4
HNSC	KLHDC1 →	+0.424	+0.557	.002	.002	2	5
LSCC	RBMS3 →	+0.421	+0.519	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001214 vs ACTA2-AS1 — HNSC

Explore this scatter interactively →