Regulation of vasculogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of vasculogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMA4, NID1, and VCL, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vasculogenesis activity versus LAMA4 in GBM (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LAMA4 →	+0.619	+0.083	.001	<.001	3	9
CCRCC	NID1 →	+0.411	+0.060	<.001	<.001	3	9
UCEC	VCL →	+0.407	+0.064	.004	.002	3	8
UCEC	KANK2 →	+0.490	+0.055	<.001	.002	3	8
GBM	LAMB1 →	+0.686	+0.092	<.001	<.001	3	8
GBM	NID2 →	+0.449	+0.054	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001212 vs LAMA4 — GBM

Explore this scatter interactively →