Regulation of vasculogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of vasculogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THOP1, SLC25A39, and EEF1AKMT4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vasculogenesis activity versus THOP1 in HNSC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	THOP1 →	-0.676	-0.532	.001	.002	3	6
HNSC	SLC25A39 →	-0.664	-0.571	.003	.002	2	6
HNSC	EEF1AKMT4 →	-0.806	-0.559	.002	.006	3	5
UCEC	MCM4 →	-0.743	-0.633	<.001	.009	3	5
UCEC	TSHZ3 →	+0.727	+0.872	.001	<.001	3	5
UCEC	DKC1 →	-0.658	-0.912	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001212 vs THOP1 — HNSC

Explore this scatter interactively →