Regulation of vasculogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of vasculogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS13, CRAMP1, and APIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS13 grouped by Regulation of vasculogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RPS13 →	-0.760	-1.461	.004	.002	3	5
LUNG_NSCLC_LUAD	CRAMP1 →	+0.484	+1.002	.007	<.001	3	4
URINARY_TRACT	APIP →	-1.137	-1.935	.001	<.001	3	4
OVARY	WBP4 →	-0.535	-1.091	.003	.001	3	4
BONE	CA13 →	+0.958	+1.617	.008	.001	3	4
KIDNEY	ZBTB44 →	+1.042	+1.364	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS13 by Regulation of vasculogenesis activity — LIVER

Explore this box plot interactively →