Regulation of vasculogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of vasculogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMBIM1, RHBDF1, and PPP1R13L, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vasculogenesis activity versus TMBIM1 in STOMACH (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMBIM1 →	+1.854	+0.176	.008	<.001	3	13
BONE	RHBDF1 →	+2.341	+0.180	.001	.001	3	11
STOMACH	PPP1R13L →	+3.030	+0.209	<.001	<.001	3	11
SOFT_TISSUE	SERINC3 →	+0.956	+0.124	<.001	<.001	3	10
BONE	ADM →	+2.674	+0.116	.001	<.001	3	10
BONE	MYOF →	+4.183	+0.155	.004	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001212 vs TMBIM1 — STOMACH

Explore this scatter interactively →