Regulation of vasculogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of vasculogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPSTI1, PRRG2, and MAPK7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vasculogenesis activity versus EPSTI1 in LARGE_INTESTINE (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EPSTI1 →	+1.707	+0.287	.005	.002	3	7
OVARY	PRRG2 →	+2.691	+0.367	<.001	<.001	3	6
URINARY_TRACT	MAPK7 →	-0.908	-0.369	.002	.004	3	6
URINARY_TRACT	CSGALNACT2 →	-0.970	-0.445	.004	.007	3	6
URINARY_TRACT	PKP3 →	+3.554	+0.568	.009	.003	3	6
URINARY_TRACT	CDH3 →	+5.970	+0.451	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001212 vs EPSTI1 — LARGE_INTESTINE

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