Negative regulation of osteoclast development

Across TCGA patient cohorts, RNA activity of the Negative regulation of osteoclast development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL16, SASH3, and SEPTIN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of osteoclast development activity versus IL16 in LSCC (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IL16 →	+0.623	+0.156	<.001	<.001	3	10
OV	SASH3 →	+0.481	+0.080	.008	<.001	3	9
LSCC	SEPTIN1 →	+0.819	+0.161	<.001	<.001	3	9
GBM	DOK2 →	+0.637	+0.077	<.001	<.001	3	9
GBM	HCLS1 →	+0.675	+0.084	<.001	<.001	3	9
UCEC	LPXN →	+0.522	+0.092	.003	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001205 vs IL16 — LSCC

Explore this scatter interactively →