Negative regulation of osteoclast development

Across TCGA cell cohorts, RNA activity of the Negative regulation of osteoclast development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTX1, ACAT1, and ANKRD11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DTX1 grouped by Negative regulation of osteoclast development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DTX1 →	+0.792	+1.252	.004	.005	2	5
LARGE_INTESTINE	ACAT1 →	-1.355	-1.468	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ANKRD11 →	-0.969	-1.577	.001	.001	3	4
LUNG_NSCLC_LUAD	PPP1R7 →	-0.362	-0.993	.005	<.001	3	4
LUNG_NSCLC_LUAD	ARHGAP17 →	-0.769	-1.365	.001	<.001	3	4
STOMACH	DYNLL1 →	-0.552	-1.302	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DTX1 by Negative regulation of osteoclast development activity — KIDNEY

Explore this box plot interactively →