Negative regulation of osteoclast development

Across TCGA cell cohorts, RNA activity of the Negative regulation of osteoclast development pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLRG1, ADRM1, and TMEM182, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLRG1 grouped by Negative regulation of osteoclast development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PLRG1 →	-0.216	-0.757	<.001	.001	3	4
OVARY	ADRM1 →	+0.210	+0.788	.009	.005	2	5
OVARY	TMEM182 →	-0.197	-0.614	.003	.008	3	4
BREAST	ZNF564 →	+0.124	+0.977	.004	.001	2	5
PANCREAS	KIF27 →	-0.259	-1.267	.001	<.001	3	3
BLOOD_Lymphoma	NEDD4L →	-0.369	-0.269	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLRG1 by Negative regulation of osteoclast development activity — SKIN

Explore this box plot interactively →