Regulation of osteoclast development

Across TCGA patient cohorts, RNA activity of the Regulation of osteoclast development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HCLS1, IL16, and SAMHD1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoclast development activity versus HCLS1 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HCLS1 →	+0.494	+0.056	<.001	.002	3	9
LSCC	IL16 →	+0.595	+0.131	<.001	<.001	3	9
LSCC	SAMHD1 →	+0.365	+0.113	<.001	<.001	3	8
LSCC	WDFY4 →	+0.475	+0.137	<.001	<.001	3	8
LSCC	WIPF1 →	+0.332	+0.114	<.001	<.001	3	8
GBM	AIF1 →	+0.539	+0.060	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001204 vs HCLS1 — UCEC

Explore this scatter interactively →