Regulation of osteoclast development

Across TCGA patient cohorts, RNA activity of the Regulation of osteoclast development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AQP9, HMOX1, and PLAUR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of osteoclast development activity versus AQP9 in GBM (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AQP9 →	+1.039	+0.542	.001	.003	3	5
GBM	HMOX1 →	+1.169	+0.608	<.001	.002	3	5
GBM	PLAUR →	+0.943	+0.626	<.001	<.001	3	4
COAD	SNAI1 →	+0.623	+0.477	<.001	.009	3	4
UCEC	CDKN2AIPNL →	-0.522	-0.910	<.001	<.001	3	4
HNSC	BCL2A1 →	+1.224	+0.525	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001204 vs AQP9 — GBM

Explore this scatter interactively →