Positive regulation of dendritic cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LGALS9, SP100_S171, and ZNF638_S299, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic cell differentiation activity versus LGALS9 in BRCA (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LGALS9 →	+0.505	+0.066	<.001	<.001	3	5
GBM	SP100_S171 →	+0.637	+0.053	.006	<.001	3	4
LSCC	ZNF638_S299 →	+0.817	+0.101	<.001	<.001	3	4
LUAD	CAST_S577 →	+0.819	+0.083	<.001	<.001	3	4
BRCA	FKBP4 →	-0.470	-0.053	.001	<.001	3	4
COAD	SMAP2_S214 →	-0.375	-0.034	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001200 vs LGALS9 — BRCA

Explore this scatter interactively →