Positive regulation of dendritic cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOX, TGFBI, and GLIPR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LOX grouped by Positive regulation of dendritic cell differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LOX →	-3.868	-1.169	.001	.002	2	6
LUNG_NSCLC_LUSC	TGFBI →	-4.593	-1.169	<.001	.002	3	4
LUNG_NSCLC_LUSC	GLIPR1 →	-2.503	-1.131	<.001	.004	3	4
SOFT_TISSUE	GNA12 →	-1.363	-1.211	.002	.007	3	4
LUNG_NSCLC_LUSC	DAPK3 →	-1.236	-1.110	<.001	.005	3	4
LUNG_NSCLC_LUSC	SFXN4 →	+0.894	+1.084	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LOX by Positive regulation of dendritic cell differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →