Negative regulation of dendritic cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of dendritic cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1_S23, SASH3, and SERPINB9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendritic cell differentiation activity versus SAMSN1_S23 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SAMSN1_S23 →	+0.844	+0.052	<.001	.002	3	9
GBM	SASH3 →	+0.585	+0.145	<.001	<.001	3	9
OV	SERPINB9 →	+0.543	+0.094	<.001	<.001	3	9
UCEC	SKAP2 →	+0.856	+0.332	<.001	.007	3	9
GBM	WAS →	+0.707	+0.148	<.001	<.001	3	9
UCEC	BTK →	+0.626	+0.262	<.001	.008	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001199 vs SAMSN1_S23 — BRCA

Explore this scatter interactively →