Negative regulation of dendritic cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of dendritic cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB1, TMEM176B, and FCGR2B, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LILRB1 grouped by Negative regulation of dendritic cell differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LILRB1 →	-0.334	-1.450	<.001	<.001	3	12
SOFT_TISSUE	TMEM176B →	-0.602	-1.809	.005	.002	3	10
KIDNEY	FCGR2B →	-0.255	-1.698	<.001	<.001	3	9
LUNG_NSCLC_LUAD	C9orf40 →	-0.317	-1.274	<.001	<.001	3	6
LUNG_NSCLC_LUAD	PDZD7 →	-0.282	-1.439	<.001	<.001	3	6
PANCREAS	HLA-G →	-0.150	-1.137	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LILRB1 by Negative regulation of dendritic cell differentiation activity — CNS

Explore this box plot interactively →