Negative regulation of dendritic cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of dendritic cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP160, ADGRG2, and SPHK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUP160 grouped by Negative regulation of dendritic cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUP160 →	+0.273	+1.585	.003	.003	3	4
BLOOD_Lymphoma	ADGRG2 →	+0.260	+2.378	<.001	<.001	3	3
BLOOD_Lymphoma	SPHK2 →	-0.297	-2.285	.005	<.001	3	3
LARGE_INTESTINE	NEFH →	-0.272	-1.925	<.001	<.001	3	3
LARGE_INTESTINE	HNF1A →	+0.274	+1.604	.002	<.001	3	3
BLOOD_Leukemia	MED12L →	-0.244	-1.522	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUP160 by Negative regulation of dendritic cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →