Regulation of dendritic cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of dendritic cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-F, PSMB9, and PARP14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic cell differentiation activity versus HLA-F in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HLA-F →	+1.052	+0.129	.001	.008	3	7
HNSC	PSMB9 →	+1.317	+0.082	<.001	<.001	3	6
HNSC	PARP14 →	+0.711	+0.060	.004	.001	3	6
HNSC	UBE2L6 →	+1.154	+0.072	.006	.002	3	6
HNSC	SAMD9L →	+1.018	+0.089	.001	.001	3	6
BRCA	PSMB8 →	+0.887	+0.128	.004	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001198 vs HLA-F — BRCA

Explore this scatter interactively →