Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Across TCGA patient cohorts, RNA activity of the Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, SP110_S380, and STK10, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell activity versus SKAP2 in GBM (Pearson r = 0.84).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SKAP2 →	+0.900	+0.182	<.001	<.001	3	10
LSCC	SP110_S380 →	+0.629	+0.118	<.001	<.001	3	10
LSCC	STK10 →	+0.534	+0.149	<.001	<.001	3	10
HNSC	TRIM21 →	+0.387	+0.079	<.001	<.001	3	10
BRCA	TRPM2_S38 →	+1.014	+0.100	<.001	<.001	3	10
GBM	WAS →	+0.793	+0.194	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001188 vs SKAP2 — GBM

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