Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Across TCGA patient cohorts, RNA activity of the Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIN3, SIRPB1, and SAMHD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell activity versus RIN3 in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RIN3 →	+0.529	+0.149	<.001	<.001	3	6
LSCC	SIRPB1 →	+0.330	+0.060	<.001	.001	3	6
HNSC	SAMHD1 →	+0.618	+0.165	<.001	<.001	3	6
GBM	MS4A4E →	+1.043	+0.177	<.001	<.001	3	6
HNSC	HAVCR2 →	+0.898	+0.148	<.001	<.001	3	6
GBM	SIGLEC8 →	+1.578	+0.176	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001188 vs RIN3 — GBM

Explore this scatter interactively →