Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Across TCGA cell cohorts, RNA activity of the Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS14, HNF1A, and CRYL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell activity versus ADAMTS14 in LARGE_INTESTINE (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAMTS14 →	-1.936	-0.303	.007	.009	3	2
LARGE_INTESTINE	HNF1A →	+3.440	+0.287	<.001	.009	3	2
LARGE_INTESTINE	CRYL1 →	+2.314	+0.301	.003	.008	2	3
LARGE_INTESTINE	BEST1 →	+1.183	+0.334	.002	.004	3	2
LARGE_INTESTINE	SPRR2E →	-0.893	-0.236	.002	.004	3	2
LARGE_INTESTINE	GGT1 →	+2.858	+0.314	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001188 vs ADAMTS14 — LARGE_INTESTINE

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