"Positive regulation of CD8-positive, alpha-beta T cell activation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, SNX20, and PLA2G7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD8-positive, alpha-beta T cell activation" activity versus ARHGAP9 in HNSC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP9 →	+0.545	+0.406	.001	.002	3	7
HNSC	SNX20 →	+0.698	+0.492	<.001	<.001	3	7
HNSC	PLA2G7 →	+0.852	+0.532	.003	.002	3	6
CCRCC	LRRC25 →	+0.561	+0.689	.001	<.001	3	6
HNSC	HLA-F →	+1.334	+0.524	<.001	<.001	3	6
CCRCC	LAPTM5 →	+0.530	+0.584	.002	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001187 vs ARHGAP9 — HNSC

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