"Positive regulation of CD8-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF6, EIF5, and S100B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF6 grouped by "Positive regulation of CD8-positive, alpha-beta T cell activation"-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RNF6 →	+0.792	+2.093	<.001	<.001	3	4
LUNG_SCLC	EIF5 →	+1.042	+1.229	.003	.002	3	4
SOFT_TISSUE	S100B →	-0.502	-1.594	.001	<.001	3	4
LIVER	NOA1 →	-0.492	-1.323	.009	.001	3	4
SKIN	CD101 →	+0.717	+1.157	<.001	<.001	3	3
BLOOD_Leukemia	CACNB3 →	+1.829	+1.282	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF6 by "Positive regulation of CD8-positive, alpha-beta T cell activation" activity — BLOOD_Lymphoma

Explore this box plot interactively →