"Positive regulation of CD8-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTLC1, CHST15, and SRPRB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPTLC1 grouped by "Positive regulation of CD8-positive, alpha-beta T cell activation"-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPTLC1 →	+0.226	+0.274	.003	<.001	3	5
URINARY_TRACT	CHST15 →	+0.113	+0.163	<.001	<.001	3	4
KIDNEY	SRPRB →	-0.373	-0.170	.002	.003	3	4
BREAST	SLC25A37 →	+0.137	+0.139	.001	.007	3	4
PANCREAS	TELO2 →	-0.185	-0.192	<.001	<.001	3	4
PANCREAS	GLUD1P2 →	+0.154	+0.110	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPTLC1 by "Positive regulation of CD8-positive, alpha-beta T cell activation" activity — OESOPHAGUS

Explore this box plot interactively →