"Positive regulation of CD8-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB8, EFCAB13, and HLA-A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of CD8-positive, alpha-beta T cell activation" activity versus PSMB8 in SOFT_TISSUE (Pearson r = 0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PSMB8 →	+5.403	+1.906	<.001	<.001	2	7
CNS	EFCAB13 →	+0.939	+0.177	.001	.003	3	5
BREAST	HLA-A →	+4.151	+1.543	<.001	<.001	3	5
BREAST	SGCB →	+2.660	+1.235	.001	.001	3	4
BREAST	AGR3 →	-4.250	-1.061	.005	.001	3	4
BLOOD_Myeloma	HLA-F →	+3.961	+0.283	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001187 vs PSMB8 — SOFT_TISSUE

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