"Negative regulation of CD8-positive, alpha-beta T cell activation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1_S23, SPN, and STX11, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD8-positive, alpha-beta T cell activation" activity versus SAMSN1_S23 in UCEC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAMSN1_S23 →	+0.890	+0.135	<.001	<.001	3	10
OV	SPN →	+0.643	+0.052	<.001	<.001	3	10
BRCA	STX11 →	+0.658	+0.084	<.001	<.001	3	10
BRCA	TAP2 →	+0.721	+0.056	<.001	<.001	3	10
BRCA	TAPBP →	+0.578	+0.057	<.001	<.001	3	10
GBM	TRIM21 →	+0.401	+0.084	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001186 vs SAMSN1_S23 — UCEC

Explore this scatter interactively →