"Negative regulation of CD8-positive, alpha-beta T cell activation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF14, IL1RN, and DDN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD8-positive, alpha-beta T cell activation" activity versus TNFSF14 in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFSF14 →	+1.025	+0.672	<.001	<.001	3	6
LSCC	IL1RN →	+1.345	+1.031	<.001	<.001	3	6
LSCC	DDN →	-0.415	-0.891	<.001	<.001	3	5
GBM	ACTG1P25 →	-0.504	-0.889	<.001	<.001	3	5
COAD	AQP9 →	+1.641	+0.201	<.001	<.001	3	5
GBM	LILRB1 →	+0.859	+0.629	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001186 vs TNFSF14 — GBM

Explore this scatter interactively →