"Negative regulation of CD8-positive, alpha-beta T cell activation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP1, MORN3, and IFIT1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of CD8-positive, alpha-beta T cell activation" activity versus AKAP1 in LUNG_NSCLC_LUAD (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AKAP1 →	+0.551	+0.586	.002	<.001	3	3
LUNG_NSCLC_LUAD	MORN3 →	-0.558	-0.564	.002	<.001	3	3
PANCREAS	IFIT1 →	+2.495	+0.434	.004	.009	3	3
LUNG_NSCLC_LUAD	MAP2 →	-3.308	-0.719	.003	<.001	3	3
LUNG_NSCLC_LUAD	PIH1D1 →	+0.735	+0.618	.006	.003	3	2
LUNG_NSCLC_LUAD	LANCL2 →	-0.979	-0.595	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001186 vs AKAP1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →