"Regulation of CD8-positive, alpha-beta T cell activation"

Across TCGA patient cohorts, RNA activity of the "Regulation of CD8-positive, alpha-beta T cell activation" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and SAMSN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD8-positive, alpha-beta T cell activation" activity versus RCSD1 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1 →	+0.650	+0.065	<.001	<.001	3	10
OV	RCSD1_S351 →	+0.722	+0.061	<.001	<.001	3	10
COAD	SAMSN1 →	+0.973	+0.047	<.001	.001	3	10
UCEC	SAMSN1_S107 →	+1.019	+0.142	<.001	<.001	3	10
BRCA	SAMSN1_S23 →	+1.001	+0.071	<.001	<.001	3	10
OV	SASH3 →	+0.590	+0.083	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001185 vs RCSD1 — OV

Explore this scatter interactively →