Regulation of ATP biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of ATP biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHANK3_S1503, ABLIM1, and VCAN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATP biosynthetic process activity versus SHANK3_S1503 in UCEC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SHANK3_S1503 →	+0.754	+0.067	.009	.007	3	5
GBM	ABLIM1 →	+0.479	+0.076	<.001	<.001	3	5
COAD	VCAN →	+0.386	+0.017	.007	.009	3	4
COAD	APBB1 →	+0.628	+0.073	.009	.001	3	4
UCEC	DACT3_S165 →	+0.673	+0.051	.002	.004	3	4
GBM	CDK1 →	-0.695	-0.058	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001169 vs SHANK3_S1503 — UCEC

Explore this scatter interactively →