Regulation of ATP biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of ATP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA7L, EIF4BP2, and DEPDC1P1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATP biosynthetic process activity versus CDCA7L in OV (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDCA7L →	+0.564	+0.083	.004	.008	3	3
OV	EIF4BP2 →	+0.728	+0.081	.001	.006	3	3
OV	DEPDC1P1 →	+0.382	+0.083	.004	.003	3	3
CCRCC	LAPTM5 →	-0.456	-0.076	.004	.005	3	3
GBM	MIR643 →	+0.669	+0.143	.001	.009	3	3
COAD	TLR7 →	-0.620	-0.371	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001169 vs CDCA7L — OV

Explore this scatter interactively →