Regulation of ATP biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of ATP biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDIPT, MESP1, and SLC4A1AP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATP biosynthetic process activity versus CDIPT in URINARY_TRACT (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CDIPT →	+0.990	+0.199	<.001	.002	3	5
LUNG_NSCLC_LUSC	MESP1 →	+1.150	+0.372	.008	.006	3	5
BLOOD_Myeloma	SLC4A1AP →	-0.731	-0.167	.005	.006	3	4
LUNG_NSCLC_LUSC	PRKACB →	+1.365	+0.284	.007	.005	3	4
LUNG_NSCLC_LUSC	CASTOR3 →	+1.319	+0.369	.007	.008	3	4
LUNG_SCLC	OTULINL →	+1.862	+0.253	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001169 vs CDIPT — URINARY_TRACT

Explore this scatter interactively →