Regulation of phospholipid transport

Across TCGA patient cohorts, RNA activity of the Regulation of phospholipid transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNL2P1, GPR55, and VMP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid transport activity versus CCNL2P1 in GBM (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CCNL2P1 →	+0.697	+0.296	<.001	<.001	3	5
CCRCC	GPR55 →	+0.289	+0.150	.001	.003	3	4
GBM	VMP1 →	-0.751	-0.257	<.001	.001	3	4
LSCC	C4BPA →	+1.599	+0.272	<.001	<.001	3	4
GBM	ENPP2 →	+1.635	+0.556	<.001	<.001	3	4
UCEC	NFXL1 →	-0.439	-0.145	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001138 vs CCNL2P1 — GBM

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