Regulation of phospholipid transport

Across TCGA patient cohorts, RNA activity of the Regulation of phospholipid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKCD_S645, PRKCD_T507, and PRKCD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid transport activity versus PRKCD_S645 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRKCD_S645 →	+0.625	+0.368	<.001	.001	3	6
OV	PRKCD_T507 →	+0.959	+0.190	<.001	.003	3	6
UCEC	PRKCD →	+0.461	+0.225	<.001	<.001	3	5
LSCC	PSME3 →	-0.389	-0.273	<.001	<.001	3	4
BRCA	TMEM201 →	-0.388	-0.189	.001	.001	3	4
LUAD	CENPQ →	-0.691	-0.172	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001138 vs PRKCD_S645 — LSCC

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